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Effects of antioxidant in relieving side effects of bleaching in smokers and non speakers

Effect of anti-oxidant on bleaching efficacy, post-operative tooth sensitivity and oxidative stress in smokers and non-smokers - a split-mouth triple blind randomized control trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047293
Enrollment
60
Registered
2022-11-14
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Bleaching Agent: Hydrogen peroxide, a strong oxidizing agent undergoes ionic dissociation in giving rise to free radicals such as nascent oxygen, hydroxyl radical, per-hydroxyl, and sup

Sponsors

Dr Ritesh Nagpal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patient having good general and oral health (ASA I). Relevant teeth should be free of restorations or/and caries and without periodontal disease. Participants will be required to have maxillary anterior teeth with a shade A3 or darker Smokers should have a habit of smoking a minimum of 10 cigarettes/day for a period of = 5 years

Exclusion criteria

Exclusion criteria: Patient with poor oral hygiene Patient less than 18 years of age Pregnant or lactating women Pre-operative tooth sensitivity Severely stained teeth such as tetracycline staining and fluorosis Previously bleached teeth Patients who are taking medications with an analgesic or anti-inflammatory effect

Design outcomes

Primary

MeasureTime frame
1. Tooth Sensitivity 2. Levels of Biomarker(8-OHdG)Timepoint: 1. Tooth Sensitivity will be assessed at the following time intervals during the course of the study: i. 10 min after bleaching ii. 1 hour after bleaching iii. 24 hours after bleaching iv. 48 hours after bleaching 2. Level of Biomarke(8-OHdG) will be assessed at the following time intervals during the course of the study: i. Before bleaching (T0) ii. 10 min after bleaching (T1) iii. 2 days after bleaching (T2)

Secondary

MeasureTime frame
1. Evaluation of change in Shade (?E)Timepoint: The change in shade will be evaluated at the following intervals i. Before bleaching ii. 1 week after first session iii. 1 week after second session iv. 1 month after bleaching

Countries

India

Contacts

Public ContactDr Sonali Taneja

ITS Centre for Dental Studies and Research

sonalitaneja@its.edu.in9891688100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026