Injectable autologus platelet concentrate as an adjunct to periodontal flap surgery in the management of periodontitis

Injectable-platelet rich fibrin (i-prf) as an adjunct to open flap debridement (ofd) in the management of periodontal osseous defects not indicated for regenerative therapy :a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/11/047236

Enrollment

Registered

2022-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Adjunctive injectable platelet rich fibrin (i PRF ) application: In addition to the procedures undertaken for the control group , the test group will receive adjunctive i PRF applicatio

Eligibility

Inclusion criteria

Inclusion criteria: 1)Adults above 18years diagnosed with periodontitis (according to AAP,2017 classification) with residual probing pocket depth (PPD) >= 5 mm after step 1 and 2 therapy (non surgical phase) in at least two adjacent interproximal sites in either of the jaws 2) Systemically healthy subjects 3) Deep pockets associated with horizontal bone defects that are not indicated for regenerative therapy 4) Full Mouth Bleeding Score

Exclusion criteria

Exclusion criteria: 1) Current tobacco users 2) Subjects taking medications affecting the periodontium (Bisphosphonates ,Calcium channel blockers ,cyclosporine ,phenytoin, steroids) 3) Pregnancy or lactation 4) Antibiotic medication in the last 3 months 5) Grade II/III furcation involvement 6) Infra bony defects that are indicated for resective or regenerative therapy.

Design outcomes

Primary

Measure	Time frame
Probing pocket depth reductionTimepoint: 6 months	—

Secondary

Measure	Time frame
1)Clinical attachment gain 2)Gingival recession 3)Pocket closureTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Keerthana Varma KC

Goverment Dental College , Kottayam

baijurm@gmail.com9447279605

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026