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Combined effect of Intraoperative drugs Milrinone- Terlipressin on blood loss during hepatic resection.

Combined effect of Intraoperative Milrinone- Terlipressin on blood loss, hepato-splanchnic and systemic hemodynamics during hepatic resection- A triple-blind randomised control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047220
Enrollment
36
Registered
2022-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C228- Malignant neoplasm of liver, primary, unspecified as to type Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Terlipressin and Milrinone: Will receive Terlipressin 1mg loading over 30 mins followed by 2u/kg/hr and Milrinone 25u/kg loading dose followed by 0.5u/kg/min maintenance till end of res

Sponsors

PGIMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I/II Patients posted for major or minor elective hepatic resection.

Exclusion criteria

Exclusion criteria: 1. Patients with portal hypertension 2. Patients with symptomatic CAD, valvular heart disease and Hypertension ( >160/90 despite two anti-hypertensives) 3. Pre-existing severe hepatic or renal insufficiency ( Child Pugh B or C, GFR < 60)

Design outcomes

Primary

MeasureTime frame
Blood loss during hepatic resection.Timepoint: After completion of hepatic resection—

Secondary

MeasureTime frame
Arterial lactate, pH and base deficit.Timepoint: Measurements will be done at three time points after obtaining a baseline reading T0- once the liver hilum is exposed T30- after 30 minutes of starting drug infusion Te- after completion of hepatic resection;AST, ALT, Urea, CreatinineTimepoint: One baseline reading followed by post-op readings till day 3;Intraoperative blood units transfusedTimepoint: After completion of hepatic resection;MAP, HR, CVPTimepoint: Intraoperatively every 10 minutes during surgery;Portal Venous lactate levelTimepoint: Measurements will be done at three time points after obtaining a baseline reading T0- once the liver hilum is exposed T30- after 30 minutes of starting drug infusion Te- after completion of hepatic resection;Portal venous pressureTimepoint: Measurements will be done at three time points. T0- once the liver hilum is exposed T30- after 30 minutes of starting drug infusion Te- after completion of hepatic resection;Surgical bleeding scoreTimepoint: After completion of hepatic resection;Urine outputTimepoint: Intraoperatively hourly during surgery—

Countries

India

Contacts

Public ContactVanni S Jhawar

Pgimer Chandigarh

ashish09399@gmail.com9914406496

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026