Health Condition 1: C159- Malignant neoplasm of esophagus, unspecified Health Condition 2: C343- Malignant neoplasm of lower lobe,bronchus or lung Health Condition 3: C155- Malignant neoplasm of lower thirdof esophagus Health Condition 4: C340- Malignant neoplasm of main bronchus Health Condition 5: C342- Malignant neoplasm of middle lobe,bronchus or lung Health Condition 6: C154- Malignant neoplasm of middle thirdof esophagus Health Condition 7: C348- Malignant neoplasm of overlappingsites of b
Conditions
Interventions
Intervention1: Individualized PEEP will be applied that is the one corresponding maximum lung compliance: In this group, once the OLV has started and the patient is haemodynamically stable HR 60/min a
Sponsors
All India Institute Of Medical Sciences delhi
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing elective thoracotomy surgery with OLV lobectomy metastatectomy esophagectomy chest wall resection surgery ASA Physical Status I, II and III
Exclusion criteria
Exclusion criteria: Patients who do not give consent for the study Patients with Body Mass Index (BMI) 35 kg/m2 Patients with moderate to severe derangements in Pulmonary Function Tests Moderate to severe ARDS Presence of bullae, pneumothorax in Chest Xray or CT scan Severe COPD patients COPD patients requiring oxygen therapy or CPAP Previous lung resection surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the impact of alveolar recruitment followed by individualised PEEP on the oxygenation during and after OLVTimepoint: 24 hours from surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in driving pressure, plateau pressure, peak pressure at selected time pointsTimepoint: 24 hours from surgery;Change in haemodynamic parameters PPV MAP HR SpO2Timepoint: T1 5 minutes after induction supine TLV T2 lateral decubitus, OLV 30 minutes after recruitment and PEEP titration T3 at the end of OLV TLV supine after recruitment and re-PEEP titration ;Change in pH, PaO2, PCO2, lactate at selected time pointsTimepoint: T1 5 minutes after induction, supine, TLV T2 lateral decubitus, OLV 30 minutes after recruitment and PEEP titration T3 at the end of OLV TLV supine, after recruitment and re-PEEP titration ;Post-operative pulmonary complicationsTimepoint: 30 days from surgery | — |
Countries
India
Contacts
Public ContactPratishtha Yadav
Dr. BR Ambedkar Institute Rotary Cancer Hospital AIIMS
Outcome results
None listed