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Effect of melatonin in situ gel in the treatment of periodontitis.

Evaluation of regenerative potential of melatonin in-situ gel in the treatment of periodontal intrabony defects- A randomised clinical trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047171
Enrollment
36
Registered
2022-11-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K055- Other periodontal diseases

Interventions

Intervention1: Melatonin in-situ gel formulation : 1.2mg ,once intraorally to the defects. Control Intervention1: In-situ gel without melatonin formulation.: 1.2mg, once intraorally to the defects.

Sponsors

Dr KAVERI G S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients of age group >= 18 years 2 Patients diagnosed with stage III periodontitis according to AAP 2017 classification. 3 Patients with probing pocket depth >= 5mm with radiographic evidence of vertical bone loss. 4 No history of periodontal surgery in past 6 months

Exclusion criteria

Exclusion criteria: 1) Smokers 2) Pregnant and lactating females 3) Patients with systemic diseases 4) Treatment with any drug that might alter melatonin levels ( eg: Diazepam)

Design outcomes

Primary

MeasureTime frame
RADIOGRAPHIC BONE FILLTimepoint: 12 weeks and 24 weeks—

Secondary

MeasureTime frame
PROBING POCKET DEPTHTimepoint: 6 MONTHS—

Countries

India

Contacts

Public ContactDr Kaveri G S

SDM COLLEGE OF DENTAL SCIENCES AND HOSPITAL

kaveri.guddada@gmail.com8971353382

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026