Health Condition 1: O- Medical and Surgical
Conditions
Interventions
None listed
Sponsors
Indian Council of Medical Research Department of Health Research (ICMR)
Eligibility
Inclusion criteria
Inclusion criteria: Adult ASA I, II patients undergoing elective surgery under proposed spinal anaesthesia, involving patients with a history of scorpion bite/s and without such a history.
Exclusion criteria
Exclusion criteria: 1. Emergency surgeries 2. Anomalies of vertebral column 3. Blood or CSF tap during the procedure 4. Patient on anti-coagulants or with bleeding diathesis 5. Patientâ??s refusal to procedure 6. Patients with psychological disorders 7. Patients with opioid abuse/ dependency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Incidence of failed subarachnoid block 2.Time of onset of sensory and motor blockade after subarachnoid block 3.Peaks of sensory and motor block, assessed by pin prick method and modified Bromage method respectively. 4.Study of voltage gated sodium channels to see for mutations. Timepoint: For Primary Outcome No:- 1,2,3 Baseline, 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes,12 minutes,14 minutes, 16 minutes, 18 minutes and 20 minutes. 2.Batch testing of 10 blood samples for Genotyping of Voltage-gated sodium channels gene would be done. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time needed for onset of adequate sensory and motor blockade after subarachnoid block 2.Association of mutations in sodium channel with failed subarachnoid block. Timepoint: For secondary outcomes no:- 1. baseline, 2 min, 4 min, 6 min, 8 min, 10 min, 12 min, 16 min, 18 min, 20 minutes after spinal anesthesia 2. 3 month, 6 month, 9 month, 12 month, 15 month, 18 month, 24 months from start of the study | — |
Countries
India
Contacts
Public ContactShikha Jain
All India Institute of Medical Sciences (AIIMS) Bhopal
Outcome results
None listed