Health Condition 1: K279- Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
Conditions
Interventions
Intervention1: Regimen for H.pylori: Levofloxacin based therapy.
Tab amoxicillin 1 g twice a day
Tab levofloxacin 500 mg twice a day
Cap omeprazole 20 mg twice a day -
all for 14 days in 1 arm cons
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: adult patients of age 18-80 years with peptic ulcer disease will be included
Exclusion criteria
Exclusion criteria: 1.Previous eradication therapy. 2.Patients who have used antibiotics within the previous 4 weeks. 3.Past history of developing allergy to any antibiotic used in the study. 4.Patients who have undergone gastrectomy. 5.Coexisting of severe concomitant illness. 6. Pregnancy or lactating women. 7.Patients diagnosed with any malignancies. Patients with portal gastropathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare efficacy of H. pylori eradication between levofloxacin-based therapy and hybrid therapy in patients with upper gastrointestinal disease needing eradicationTimepoint: 6 weeks The assessment of eradication which determines the efficacy will be at 6 weeks following the completion of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the compliance and adverse effects of levofloxacin-based therapy and hybrid therapy.Timepoint: Compliance will be measured at the end of therapy (2weeks). Adverse effects will be measured during and 1 week after the therapy (1-3 weeks of commencement of therapy ) | — |
Countries
India
Contacts
Public ContactDr Rajalekshmy M R
JIPMER
Outcome results
None listed