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Does anti osteoporotic drug teriparatide helps in healing of open tibia fractures

Does teriparatide promote fracture healing in open tibia fractures? A prospective, randomized control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047097
Enrollment
152
Registered
2022-11-07
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S818- Open wound of lower leg

Interventions

Intervention1: Debridement and closed reduction and reamed intramedullary nailing of tibia with 20μg injection teriparatide: Debridement and closed reduction and reamed intramedullary nailing of the

Sponsors

Ganga Medical Centre and Hospitals Pvt Ltd
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Acute, open ( Gustilo Anderson type 1,2, and 3A) who undergo reamed intramedullary nailing with primary wound closure.

Exclusion criteria

Exclusion criteria: Patients with ipsilateral or contralateral lower extremity other than the ipsilateral fibula fracture, Wound which requires soft tissue cover, Serum calcium above reference levels, liver enzymes more than double the upper reference level

Design outcomes

Primary

MeasureTime frame
Radiological and functional assessment will be done at each follow-up. Time for union, Callus index will be noted. Functional assessment will be done using LEFS score and SF 12, and radiological assessment of union using RUST score and callus index.Timepoint: 6 weeks, 3 months, 6 months and at 1 year

Secondary

MeasureTime frame
Associated complication such as nonunion, infection, malunion , implant failure and metabolic abnormalityTimepoint: 6 weeks, 3 months, 6 months and at 1 year

Countries

India

Contacts

Public ContactDR IMRAN ASIF

Ganga Medical Centre and Hospitals Pvt. Ltd.

DR.VELMURUGESAN@GMAIL.COM9791597520

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026