Injectable autologous platelet concentrate as an adjunct to periodontal flap surgery in the management of periodontitis

Effectiveness of injectable platelet rich fibrin (i-PRF) with combination periodontal regenerative therapy in the management of infrabony defects: A randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/11/047091

Enrollment

Registered

2022-11-07

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Adjunctive injectable platelet rich fibrin(i-PRF) application: In addition to the procedures undertaken for the control group the test group will recieve adjunctive i-PRF application al

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults above18 years diagnosed with periodontitis (according to AAP 2017 classification) after step 1 and step 2 therapy (non-surgical phase) with the presence of atleast one site with 2 or 3 walled interproximal infrabony defects in either of the jaws 2. Systemically healthy subjects 3. Full mouth bleeding score

Exclusion criteria

Exclusion criteria: 1. Current tobacco users 2. Subjects taking medications affecting the periodontium (Bisphosphonates, Calcium channel blockers, cyclosporine, steroids, phenytoin ) 3. Pregnancy or lactation 4. Antibiotic medication in the last 3 months 5. Infrabony defects that are indicated for resective therapy. 6. Grade II /II furcation involvement

Design outcomes

Primary

Measure	Time frame
1. Clinical attachment gainTimepoint: 6 months	—

Secondary

Measure	Time frame
1. Probing pocket depth reduction 2. Gingival recession 3. Radiographic bone fill 4. Composite outcome measureTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Anu John

Government Dental College Kottayam

baijurm@gmail.com9447279605

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026