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A study to compare the effect of general anaesthesia and intravenous anaesthesia in oral cancer patients for perioperative inflammation

Comparison of effect of total intravenous anaesthesia using propofol and dexmeditomidine with inhalational agents on perioperative inflammation in oral cancer patients: A Randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047067
Enrollment
80
Registered
2022-11-04
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: TIVA(total intravenous anaesthesia) using BIS guided propofol and dexmedtomidine: patient will be given TIVA using propofol and dexmedetomidine (@ 0.5 mics/kg/hr) intraoperatively durin

Sponsors

All India Institute of Medical Sciences Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.All patients with ASA grade 1, 2 2.Patients of either sex 3.Age 18 to 60 years 4.Patients expected to get extubated in immediate postoperative period

Exclusion criteria

Exclusion criteria: 1. Patients refusal to participate in the study or giving consent 2. Patients with ASA grade >2 3. Patients having chronic pain or any opioid treatment 4. Patient requiring postoperative ventilation support 5. Patient with any other local or systemic infection 6. Patient with sepsis or septic shock 7. Patients on beta blockers or having bradycardiaor hypotension 8. Patient with BMI 35kg/m2 9. Patients planned for free flap reconstrucion

Design outcomes

Primary

MeasureTime frame
To compare change in value of TNF alphaTimepoint: day 1—

Secondary

MeasureTime frame
1.To compare change in value of IL6,IL 10, IL 13. 2.To compare Change in value of TNF at day 3 3. total analgesic need in both the groups at Day2 Timepoint: Day 1,2 and 3—

Countries

India

Contacts

Public ContactPriyanka Sethi

All India Institute of Medical Sciences, Jodhpur

dr.priyanka_sethi@yahoo.co.in9352206300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026