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To check whether injection Clonidine when added to local anaesthesia medicine Bupivacaine gives any additional benefit when injected in scalp tissue for brain surgery in terms of pain relief and blood pressure control

Efficacy of addition of Clonidine to Bupivacaine versus plain Bupivacaine infiltration of scalp blocks for supratentorial craniotomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047065
Enrollment
60
Registered
2022-11-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C710- Malignant neoplasm of cerebrum, except lobes and ventricles Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Bilateral scalp blocks for supratentorial craniotomy: Bilateral scalp blocks for supratentorial craniotomy with plain 0.25% (maximum dose 2mg/kg) and addition of injection Clonidine 2mc

Sponsors

Dr Chris Lemos
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II GCS 15

Exclusion criteria

Exclusion criteria: GCS Pregnant patients Allergy to any of the study drugs h/o Diabetes Mellitus h/o hypertension Emergency cases Pre-op bradycardia h/o ischemic heart diease/arrhythmias patient refusal to participate in the study Previous history of craniotomy

Design outcomes

Primary

MeasureTime frame
1.intraoperative anaesthetic requirements 2.intra-operative hemodynamic responseTimepoint: 1.intraoperative anaesthetic requirements 2.intra-operative hemodynamic response

Secondary

MeasureTime frame
to compare duration of post operative analgesia provided by local anaesthetic bupivacaine in scalp blocks with clonidine as an adjuvant to bupivacaine in patients undergoing supratentorial craniotomyTimepoint: VRS score every 4 fours upto first 24 hours in post operative period

Countries

India

Contacts

Public ContactDr Chris Lemos

Superspeciality hospital NSCB Medical college Jabalpur

draniveshjain@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026