Health Condition 1: S341- Other and unspecified injury of lumbar and sacral spinal cord
Conditions
Interventions
Intervention1: Transcranial Magnetic Stimulation: A non-invasive magnetic pulse will be applied on the scalp underlying leg area on motor homunculus for 3-5 mins for 5 consecutive days and twice a day
Sponsors
Department of Biotechnology
Eligibility
Inclusion criteria
Inclusion criteria: Complete spinal cord injury patient with ASIA impairment score A,complete motor and sensory loss below the level of injury
Exclusion criteria
Exclusion criteria: 1. Osteoporotic Fracture 2. History of neurological or orthopaedic disease related to spinal cord 3. Head injury 4. Ferromagnetic metallic implants close to the target stimulation area 5. Pacemaker 6. Cognitive impairment 7. Pregnancy 8. History/family history of seizures 9. Acute eczema/ bed shore under the target stimulation area An informed consent form will be filled by patients if they fit into the inclusion and exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This is the first research based trial using nanotechnology with iTBS for inducing locomotor recovery and also assessing changes in cortical excitability and connectivity in Complete Spinal Cord Injury patients. The proposed intervention of iTBS along with implantation of hydrogel containing neurotrophic factors and IONPs, will augment the restoration of lost functions in complete SCI patients. We expect improvement in the functions below the level of lesion; autonomic functions like urinary and bowel control, locomotion, relief from pain, and psychological well-being.Timepoint: All assessments will be done before and after the intervention. follow-up assessments will be done at 1 month, 2 months and 3 months after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| This will improve the quality of life of patients and ease the burden on public health. We presume that this non-invasive, activity-dependent strategy would be able to reduce the etiology of the disease.Timepoint: All assessments will be done before and after the intervention. follow-up assessments will be done at 1 month, 2 months, and 3 months after the intervention. | — |
Countries
India
Contacts
Public ContactDeeksha Patel
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed