Comparison between two drugs, Dexmedetoidine versus Lignocaine in supressing cough reflex after surgery when administered via breathing passage.

INTRATRACHEAL DEXMEDETOMIDINE VS INTRATRACHEAL LIGNOCAINE IN ATTENUATION OF COUGH REFLEX WHILE EXTUBATION IN PATIENTS OF ORAL AND MAXILLOFACIAL SURGERY.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/11/047035

Enrollment

140

Registered

2022-11-04

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M269- Dentofacial anomaly, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Intratracheal dexmedetomidine: 0.5mcg/kg of dexmedetomidine in 2ml saline intratracheal spray 30 minutes before extubation Control Intervention1: Intratracheal Lignocaine: 1mg/kg of 2%

Eligibility

Inclusion criteria

Inclusion criteria: Age 18-65 years ASA I-II patients Undergoing elective Oral and Maxillofacial surgery under general anesthesia

Exclusion criteria

Exclusion criteria: Lack of consent Any laryngeal pathology Active upper respiratory tract infection Pre-existing lung disease (COPD, Asthma) Cardiac conduction anomaly

Design outcomes

Primary

Measure	Time frame
Assessment of Cough on the basis of Modified Minogue ScaleTimepoint: During and up to 5 minutes after extubation	—

Secondary

Measure	Time frame
Time to extubation Time to awareness (time to follow verbal commands) heart rate, systolic and diastolic blood pressure Any adverse eventTimepoint: Up to 30 minutes from the time of extubation	—

Countries

India

Contacts

Public ContactDevalina Goswami

AIIMS New Delhi

drdevalina@gmail.com9971196699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026