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Effect of Magnesium on Lactate clearance in patients with sepsis

Effect of Magnesium on Lactate clearance in critically ill patients with sepsis : A Randomised clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047031
Enrollment
138
Registered
2022-11-03
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A419- Sepsis, unspecified organism

Interventions

Intervention1: Intravenous Magnesium sulphate: Magnesium sulphate 2 gram is diluted in 50 ml normal saline and infused intravenously over 2 hours once daily for 3 days Control Intervention1: Normal sa

Sponsors

ALL INDIA INSTITUTE OF MEDICAL SCIENCES, JODHPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with diagnosis of sepsis (change in SOFA > 2 with suspected or confirmed infection and lactate levels >2mmol/L, admitted in Adult ICU

Exclusion criteria

Exclusion criteria: Chronic renal impairment, Liver failure (child pugh B & C), pregnancy, Diabetes on metformin, diabetic keto acidosis, alcoholism, MAP <65 mmhg despite vasopressor therapy, patients who refuse to provide consent

Design outcomes

Primary

MeasureTime frame
Time to Lactate clearance (20% decrease from baseline)Timepoint: Time to Lactate clearance (20% decrease from baseline) in first 3 days from diagnosis of sepsis—

Secondary

MeasureTime frame
Changes in lactate clearance, vasopressor dose, duration of ICU stay, duration of hospital stay, MortalityTimepoint: Day 1, day 2, day 3 and day 28 from diagnosis of sepsis—

Countries

India

Contacts

Public ContactDr Ankur Sharma

ALL INDIA INSTITUTE OF MEDICAL SCIENCES, JODHPUR

ankuranaesthesia@gmail.com9654045653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026