Health Condition 1: K055- Other periodontal diseases
Conditions
Interventions
Intervention1: Mangosteen peel extract gel: Mangosteen fruit peel extract gel will be indigenously prepared in the laboratory and placed in periodontal intrabony defects following conventional flap su
Sponsors
Dr Itha Joshna
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age range of 20-65years. 2.Patients with localized or generalized periodontitis of stage-II and stage-III with grade B as per 2017 classification will be included. 3 walled and 2 walled intrabony defects with radiologic vertical bone loss of >= 3mm at baseline and a PPD >=5mm when persistent after non-surgical therapy. 3.No medications affecting periodontal status during the previous 6 months
Exclusion criteria
Exclusion criteria: 1. Uncontrolled systemic diseases 2. Traumatic occlusion 3. Patients with TMJ disorders 4. Smokers 5. Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical: Probing pocket depth (PPD) Relative clinical attachment level (rCAL) Radiographic: Defect angle Linear amount of bone fill Depth of defect after bone fill Percentage of bone fill Biomarkers: MMP-8 and OPG-1 in Gingival Crevicular Fluid Timepoint: T1-Baseline, T2-3 Months, T3-6 Months Clinical: Probing pocket depth (PPD) Relative clinical attachment level (rCAL) Radiographic: Defect angle Linear amount of bone fill Depth of defect after bone fill Percentage of bone fill Biomarkers: MMP-8 and OPG-1 in Gingival Crevicular Fluid | — |
Secondary
| Measure | Time frame |
|---|---|
| Plaque index(Silness and Loe,1964) Gingival index(Loe and Silness,1963)Timepoint: T1-Baseline, T2-3months, T3-6months Plaque index(Silness and Loe,1964) Gingival index(Loe and Silness,1963) | — |
Countries
India
Contacts
Public ContactDr Swetha P
Vishnu Dental College
Outcome results
None listed