FindTrial
Sign In

It is a comparison between topical eye drops of voriconazole and injection of voriconazole for treatment of non healing fungal corneal ulcer

â??Topical Voriconazole versus Intrastromal Voriconazole for treatment of Recalcitrant fungal corneal ulcer â?? A Randomised controlled trialâ??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/046996
Enrollment
72
Registered
2022-11-02
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: TOPICAL VORICONAZOLE EYE DROPS 1% ONCE HOURLY: FUNGICIDAL USED TOPICALLY ( TOTAL DURATION 1 WEEK) Control Intervention1: INTRASTROMAL VORICONAZOLE 0.1ML (50 MICROGRAM/0.1ML) IN EACH INJ

Sponsors

ROHILKHAND MEDICAL COLLEGE AND HOSPITAL, BAREILLY
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Presence of fungal corneal ulcer at the time of presentation (corneal epithelial defect with stromal infilteration ). 2. Patients presenting with fungal corneal ulcers which are resistant to other antifungal therapy for at least 2 weeks .

Exclusion criteria

Exclusion criteria: 1. Patients with perforated corneal ulcer, systemic diseases like uncontrolled diabetes mellitus, immunocompromised patients and patients with endophthalmitis. 2. Patients presenting with bacterial keratitis.

Design outcomes

Primary

MeasureTime frame
Improvement in clinical profileTimepoint: At 1 week—

Secondary

MeasureTime frame
Improvement in Best corrected visual acuityTimepoint: At 1 week—

Countries

India

Contacts

Public ContactDR POOJA RANI

Rohilkhand medical college and hospital,Bareilly

ashutoshdokania@gmail.com9897294857

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026