Combination Of Oneâ??s Own Dentin Autograft, I-PRF,A-PRF plus Along With & Without The Use Of A Commercial Drug, Simvastatin To Enhance Bone Formation In Socket Preservation Procedure.

A Clinico-Radiographic Evaluation Of Dentin Autograft, I-PRF, A-PRF plus With And Without Simvastatin In Socket Preservation: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046927

Enrollment

Registered

2022-10-31

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K084- Partial loss of teeth

Interventions

Intervention1: socket preservation with 1.2mg simvastatin: combination of dentin autograft, i-PRF, A-PRF+, simvastatin is used for socket preservation. clinical and CBCT measured at baseline and 4 mo

Eligibility

Inclusion criteria

Inclusion criteria: solated or multiple alveolar sockets of maxillary and mandibular single or multirooted teeth, indicated for extraction, with at least 7 mm residual alveolar bone height as measured clinically or radiographically. Residual extraction sockets possessing intact bone in all dimensions(all four walls) with alveolar bone more than 50 % of the root length. The indications for tooth extraction were root fracture and non restorable, periodontitis, and prosthetic reasons. Patient with no systemic diseases (eg- uncontrolled diabetes, uncontrolled hypertension and bleeding disorders).Patient with good oral hygiene (plaque index <1.9).

Exclusion criteria

Exclusion criteria: Patients who are smokers(more than 10 cigarettes per day), chronic alcoholics. Endodontically treated teeth indicated for extraction. Absence of more than 50% of buccal bone. Patients on drug therapy (like bisphosphonates, antiplatelets, anticoagulants, immunosuppressants) which can affect the outcome. Pregnant women and lactating mothers. Patients not willing for the study or not available for follow up.

Design outcomes

Primary

Measure	Time frame
To evaluate clinically the horizontal width and height of the alveolar socket following the placement of dentin autograft, i-PRF, A-PRF plus with and without simvastatin. Timepoint: Baseline and 4 months	—

Secondary

Measure	Time frame
To compare radiographically, the horizontal width and height of the alveolar socket following the placement of dentin autograft, i-PRF, A-PRF plus with and without simvastatin. Timepoint: Baseline and 4 months	—

Countries

India

Contacts

Public ContactDeepthi M

Rajiv Gandhi university of health sciences

2012mgtriveni@gmail.com9449019711

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026