to study the effectiveness of mannitol with routine local anesthesia in nerve blocks

Efficacy of 0.5M Mannitol as an adjuvant with lidocaine with epinephrine for intraoral nerve blocks â?? A split-mouth study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046921

Enrollment

Registered

2022-10-31

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: To compare the efficacy of lidocaine with epinephrine with 0.5 M mannitol or without mannitol as an adjuvant for intraoral nerve blocks.: Before treatment, surgical technique will be br

Eligibility

Inclusion criteria

Inclusion criteria: 1.Individuals between the ages of 16 and 35 years who have no allergy to mannitol and lidocaine will be included in the study. 2.Individuals who require bilateral local anesthetic nerve blocks within same arch.

Exclusion criteria

Exclusion criteria: 1.Subjects allergic to mannitol or lidocaine or with any underlying systemic disease or history of significant medication that would alter pain perception. 2.Pregnant and lactating mothers will be excluded from the study. 3.Patients with restricted mouth opening/ difficulty in mouth opening will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
Primary outcome: the onset of action of local anesthesia, duration of anesthesia and time required for return of sensation and overall the effectiveness of mannitol with lignocaine and epinephrine. Timepoint: day 0,1,2,3,7	—

Secondary

Measure	Time frame
Secondary outcome: Hemodynamic changes: blood pressure, heart rate, oxygen saturation preoperatively, intraoperatively (at the time of injecting local anaesthetic and after injecting local anaesthetic) and post-operatively. Post-operative discomfort or pain due to injection on Day 0, 1, 2 and 3 using printed form visual analog scale provided to the patient on the day of extraction. Post-operative complications: 1. healing 2.presence or absence of swelling 3. trismus in case of inferior alveolar nerve block Timepoint: day 1,2,3,7	—

Measure

Time frame

Secondary outcome: Hemodynamic changes: blood pressure, heart rate, oxygen saturation preoperatively, intraoperatively (at the time of injecting local anaesthetic and after injecting local anaesthetic) and post-operatively. Post-operative discomfort or pain due to injection on Day 0, 1, 2 and 3 using printed form visual analog scale provided to the patient on the day of extraction. Post-operative complications: 1. healing 2.presence or absence of swelling 3. trismus in case of inferior alveolar nerve block Timepoint: day 1,2,3,7

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Countries

India

Contacts

Public ContactDR ANAND SHUKLA

manipal college of dental sciences, manipal

srikanth.mds@manipal.edu9986455201

Outcome results