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TO EVALUATE THE OCCURRENCE OF THE DIFFERENT GENOTYPES OF THE RECEPTORS AND LIGANDS (CCL3, CCL5 AND CCR5) INVLOVED IN GUM AND SURROUNDING BONE DISEASE OF TEETH.

CC CHEMOKINE RECEPTOR 5, CC CHEMOKINE LIGANDS 3 AND 5 GENE POLYMORPHISMS IN PATIENTS WITH PERIODONTITIS- A CASE-CONTROL STUDY

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/10/046889
Enrollment
172
Registered
2022-10-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

None listed

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients of age 30-60 are to be recruited for the study. 2. Ethnic Tamilian subjects. 3. Control group to include subjects with no signs of periodontal disease and probing sulcus depth of 4. Test group to include patients with Probing Pocket Depth of >= 5mm and/or Clinical Attachment Loss of >=3mm in greater than 30% of sites with chronic periodontitis.

Exclusion criteria

Exclusion criteria: 1. Patients with any inflammatory systemic conditions such as diabetes mellitus, rheumatoid arthritis, etc. 2. Patients with immunodeficiency disorders. 3. Patients with local modifiers like food impaction, factitious habits and bruxism. 4. Patients who smoke. 5. Use of orthodontic and prosthetic appliances. 6. Patients who had taken systemic antibiotic, anti-inflammatory, hormonal or other assisted drug therapy in the last 6 months or prior to the study.

Design outcomes

Primary

MeasureTime frame
1. The distribution of genotype and allele frequencies are to be assessed. 2. Plaque Index -PI (Loe and silness,1964) 3. Modified Sulcular bleeding index -mSBI (Mombelli, 1987) 4. Probing pocket depth (PPD) 5. Clinical attachment level (CAL)Timepoint: BASELINE

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDR S SANGEETHA

SRM DENTAL COLLEGE, RAMAPURAM, CHENNAI

sangeetha_doc@yahoo.com9884563217

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026