Health Condition 1: 2- Placement
Conditions
Interventions
Intervention1: Early central venous catheter: The enrolled children will be subjected to internal jugular or subclavian venous catheterization within 1 hour of labelling fluid refractory septic shock
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Children 3 months to 12 years of age with fluid refractory septic shock (after 20-40 ml/kg crystalloid over 1 hour)
Exclusion criteria
Exclusion criteria: Contraindications for central venous catheterization Post cardiac arrest or ongoing cardiopulmonary resuscitation Primary cardiac disease Severe acute malnutrition Chronic kidney disease Chronic liver disease Already received fluid boluses and/or vasoactive drugs in referring hospital or prior to enrolment. Requirement for surgery within 6 hours of diagnosis Refused consent by the parents/guardians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shock resolution at 6 hours after CVC placementTimepoint: 6 hours after CVC placement | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Shock resolution at 2 hours of CVC placement. 2. Shock resolution at 4 hours of CVC placement. 3. Time (in hours) to achieve the therapeutic endpoints of shock resuscitation. 4. Pediatric Logistic Organ Dysfunction (PELOD) score 5. Fluid boluses needed in first 6 hours 6. Vasoactive inotrope score (VIS) 7. Need and duration of mechanical ventilation 8. Need for blood products 9. Number of dysfunctional organs 10. Rate of CLABSI 11. Duration of PICU stay 12. Duration of hospital stay 13. In-hospital mortality 14. Protocol compliance 15. Incidence of CVC related complications Timepoint: Till discharge or death | — |
Countries
India
Contacts
Public ContactSuresh Kumar
PGIMER, Chandigarh
Outcome results
None listed