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Role of Corneal Biopsy in Patients with Non healing Corneal Ulcer

Evaluating Corneal Biopsy As A Primary Diagnostic Tool In Microbial Keratitis Patients On Poly Antimicrobials

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046809
Enrollment
44
Registered
2022-10-26
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: CORNEAL BIOPSY: 3MM TISSUE WILL BE TAKEN USING AND SENT FOR CULTURE AND HISTOPATHOLOGY Control Intervention1: CORNEAL SCRAPING: CORNEAL SCRAPING WILL BE DONE AND SENT FOR CULTURE

Sponsors

DR RP CENTRE OF OPHTHALMIC SCIENCESALL INDIA INSTITUTE OF MEDICAL SCIEMCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: KERATITIS PATIENTS ON MORETHAN OR EQUAL TO 2 ANTIMICROBIALS BELONGING TO DIFFERENT CLASSES FOR MORETHAN EQUAL TO 1 WEEK WITH NO SIGNS OF HEALING CORNEAL ULCER SIZE OF 4 MM AGE MORE THAN 18 YEARS PATIENTS WILLING TO GIVE CONSENT NO PRIOR MICROBIOLOGICAL REPORT

Exclusion criteria

Exclusion criteria: HEALING KERATITIS PATIENTS WITH STROMAL THINNING MORETHAN 50 % SUSPECTED VIRAL KERATITIS

Design outcomes

Primary

MeasureTime frame
TO COMPARE CULTURE POSITIVITY RATES BETWEEN CORNEAL SCRAPING AND CORNEAL BIOPSYTimepoint: ONE TIME STUDY—

Secondary

MeasureTime frame
TO CHECK CORNEALSMEAR POSITIVITY RATESTimepoint: ONE TIME STUDY—

Countries

India

Contacts

Public ContactGANDEPALLI LAVANYA

ALL INDIA INSTITUTE OF MEDICAL SCIENCES , NEW DELHI

drpraful13@gmail.com7978735802

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026