Health Condition 1: K802- Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention1: Intravenous dexmedetomidine: Patients will be randomized into two groups. One group will receive the study drug (dexmedetomidine) and the other group will receive placebo (normal salin
Sponsors
Dr Lokeshwaran
Eligibility
Inclusion criteria
Inclusion criteria: All patients of American Society of Anaesthesiologists (ASA) physical status I and II criteria belonging to age group of 18-65 years undergoing laparoscopic surgeries under general anaesthesia.
Exclusion criteria
Exclusion criteria: Obesity(BMI >30 kg/m2), anticipated difficult airway, cardiopulmonary disease, renal or hepatic insufficiency, neurological or psychiatric disorders, hypertension (BP >140/90 mmHg), diabetes mellitus, allergy to dexmedetomidine, alcohol abuse, patients on anti-platelet drugs or steroids and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the effect of dexmedetomidine infusion on peri-operative stress response as measured by the levels of stress hormones (cortisol and Interleukin-6) at different points of time in patients undergoing laparoscopic surgeries.Timepoint: 1. Pre-operatively 2. Immediately after extubation 3. 24 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the effect of dexmedetomidine infusion on hemodynamic parameters, post-operative sedation and pain, the need for rescue analgesics.Timepoint: Before induction, after induction, during intubation, immediately after intubation, at the start of CO2 insufflation, every 5 minutes for the first 20 minutes, thereafter every 10 minutes till the release of pneumoperitoneum, at extubation, 2 hours after surgery. | — |
Countries
India
Contacts
Public ContactDr Lokeshwaran
VMMC and Safdarjung Hospital
Outcome results
None listed