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Exploring the importance of genome sequencing to predict pneumonia in children

Comparison of oral microbiota in pediatric pneumonia cases with healthy children and exploring the role of whole genome sequencing in the prediction of pediatric pneumonia.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/10/046763
Enrollment
66
Registered
2022-10-25
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system

Interventions

None listed

Sponsors

Indian Council of Medical Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Case Inclusion criteria: Cases are hospitalized children aged Control Inclusion criteria: Children less than 18 years belonging to the same family who are healthy and not suffering from any disease. If siblings are absent, healthy children from the neighborhood will be included.

Exclusion criteria

Exclusion criteria: Case Exclusion criteria: Cases were excluded if they had been hospitalized within the previous 14 days or had resolution of lower chest wall indrawing following bronchodilator therapy (for severe cases with wheeze) or had one course of antibioticsâ??children with immune-compromised status such as HIV. Control Exclusion criteria: Children with any kind of illness or any history of antibiotics or drug intake in the last one week

Design outcomes

Primary

MeasureTime frame
a. Metagenomic comparison of pediatric pneumonia cases with healthy children. b. Detection and surveillance of AMR genes in children less 18 years of age. Timepoint: 2 years

Secondary

MeasureTime frame
a. Comparing the microbiota of pediatric pneumonia cases based on etiology. b. Detection of TB bacilli if present Timepoint: 2 years

Countries

India

Contacts

Public ContactKiran Chawla

Manipal Academy of Higher Education

kiran.chawla@manipal.edu09980220484

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026