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Effect of Intravenous Versus Inhalational Anaesthetic agent on Oxygenation in Patients undergoing Thoracic Surgery

Effect of Propofol Total Intravenous versus Sevoflurane Inhalational General Anaesthesia on Arterial Oxygenation During One-Lung Ventilation in Patients undergoing Open Thoracic Surgery: A Randomized Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046752
Enrollment
100
Registered
2022-10-25
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified Health Condition 2: J869- Pyothorax without fistula

Interventions

Intervention1: Total Intravenous Anaesthesia: Infusion of Propofol 2% to Maintain BIS Between 40-60 Intervention2: Inhalational Agent: Sevoflurane Titrated to Maintain BIS between 40-60 Control Interv

Sponsors

Sir Gangaram Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Age of patient between 18-70 years. 2 All consenting patients to undergo open thoracic surgery. 3 American Society of Anaesthesiologist (ASA) physical status between 1-3. 4 Patients with unilateral lung pathology undergoing thoracic surgery.

Exclusion criteria

Exclusion criteria: 1 Patients with bilateral pulmonary pathology. 2 Patients with baseline SpO2

Design outcomes

Primary

MeasureTime frame
To compare the Arterial Oxygenation PaO2 by serial ABG, in both the groups.Timepoint: ABG to be taken at 5 predetermined time points, that is at 10 minutes of Two-lung ventilation after induction, then at 15,30,60 and 90 minutes after the start of One-lung ventilation.—

Secondary

MeasureTime frame
To compare Cardiac Output and Stroke VolumeTimepoint: 10 minutes of Two-lung ventilation, then at 15,30,60 and 90 minutes after the start of One-lung ventilation.—

Countries

India

Contacts

Public ContactNadia Ahmad

Sir Gangaram Hospital, New Delhi

drjayashreesood@gmail.com9811294608

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026