A clinical trial to compare the effects of two drugs, dexmedetomidine , a drug used in treatment of raised blood pressure and paracetamol , a drug used for pain relief in patients undergoing laparoscopic cholecystectomy.

A comparative study of the efficacy of intravenous paracetamol and dexmedetomidine alone and in combination on peri-operative haemodynamics and post-operative analgesia for patients undergoing laparoscopic cholecystectomy under general anesthesia.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046735

Enrollment

105

Registered

2022-10-21

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: Loading dose 0.5microgram/kg over 15mins before induction of anesthesia and 0.2microgram/kg/hr by continuous infusion during intraoperative persiod Control Intervention

Eligibility

Inclusion criteria

Inclusion criteria: 1.Consent to participate in the study 2.Patients scheduled for laparoscopic cholecystectomy 3.American society of anaesthesiology grade 1 and 2

Exclusion criteria

Exclusion criteria: 1.Uncooperative patient/ not able to understand pain assessment test 2.Pregnant and lactating women 3.History of any significant pulmonary, cardiovascular, neurological, hepatorenal, pshyciatric or metabolic disease. 4.Bleeding diathesis. 5.History of previous allergy to paracetamol

Design outcomes

Primary

Measure	Time frame
Dexmedetomidine and Paracetamol combination is more effective in maintaining the hemodynamic responses and intraoperative hemodynamic variables in laparoscopic cholecystectomy surgery than individual drugs.Timepoint: baseline, 24hours	—

Secondary

Measure	Time frame
Postoperative pain is minimal with combination groupTimepoint: 24hours	—

Countries

India

Contacts

Public ContactGadde venkata Harshitha

Gajra raja medical college

drjagrawal@gmail.com9300009942

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026