A glucose lowering drug named Metformin is either continued or stopped on the morning of surgery and the blood glucose and serum lactate levels are measured.

"Effect of continuing morning dose of Metformin on perioperative blood glucose and serum lactate levels in Diabetic patients posted for Minor Surgery:A Randomised Controlled Trial".

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046706

Enrollment

Registered

2022-10-21

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: METFORMIN CONTINUATION: Tab. Metformin 500mg is continued on the day of surgery and the blood glucose and serum lactate levels are measured at the baseline, 1 hour after surgical incisi

Eligibility

Inclusion criteria

Inclusion criteria: Diabetes Mellitus for more than 6 months duration using Metformin as a single agent, ASA II TO III, Serum creatinine levels < 1.6, posted for minor surgical procedures( both general and regional anaesthesia)

Exclusion criteria

Exclusion criteria: HbA1c >8%, patients with chronic or acute renal insufficiency, patients on insulin therapy, patients with liver insufficiency, patients using corticosteroids.

Design outcomes

Primary

Measure	Time frame
To study and compare changes in blood glucose levels and serum lactate levels at different time intervals in diabetic patients undergoing elective minor surgeries under general or regional anaesthesia, with or without continuation of morning dose of metformin.Timepoint: Baseline, 1 hour after incision, 2 hours postoperative and 24 hours postoperative values	—

Secondary

Measure	Time frame
To compare effect of continuing metformin in diabetic patients undergoing minor surgery on perioperative blood glucose in patients receiving general anaesthesia versus regional anaesthesia. 2) To compare effect of continuing Metformin in diabetic patients undergoing minor surgery on perioperative lactate levels in patients receiving general anaesthesia versus regional anaesthesia. 3) To study the requirement and amount of intraoperative insulin if any.Timepoint: Baseline, 1 hour after incision, 2 hours postoperative and 24 hours postoperative values	—

Measure

Time frame

To compare effect of continuing metformin in diabetic patients undergoing minor surgery on perioperative blood glucose in patients receiving general anaesthesia versus regional anaesthesia. 2) To compare effect of continuing Metformin in diabetic patients undergoing minor surgery on perioperative lactate levels in patients receiving general anaesthesia versus regional anaesthesia. 3) To study the requirement and amount of intraoperative insulin if any.Timepoint: Baseline, 1 hour after incision, 2 hours postoperative and 24 hours postoperative values

—

Countries

India

Contacts

Public ContactDRagha Renuka

Nizams Institute of Medical Sciences

abhiruchipatki2204@yahoo.co.in9177909339

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026