Health Condition 1: E43- Unspecified severe protein-caloriemalnutrition
Conditions
Interventions
Intervention1: Syp. Levocarnitine: All children 6 months to 5 years will receive syp. levocarnitine @100mg/kg/day for 3 months in 3 divided doses
Control Intervention1: Placebo Syp. similar to Syp. Le
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: All children 6 months-5 years fulfilling the WHO criteria for complicated severe acute malnutrition will be included. Complicated severe acute malnutrition is defined as children with clinical features of infection, severe anemia, metabolic disturbances, edema, hypothermia, vomiting, severe dehydration or a lack of apetitie
Exclusion criteria
Exclusion criteria: 1. Children with congenital heart disease and acquired heart disease 2. Children with chronic organ dysfunction 3. Children with congenital malformations 4. Children with chromosomal anomalies 5. Children with inborn errors of metabolism 6. Children already taking levocarnitine supplementation will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of children with weight for height more than -2 Z ScoreTimepoint: 6 months after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time to Recovery 2. Duration of Hospital Stay 3. Mortality 4. Brain Natriuretic Peptide, Creatinine Kinase MB and CTrop I 5. Left ventricular Mass, left ventricular mass index, ejection fraction and fractional shortening 6. Relapse rateTimepoint: 3 months and 6 months 3 months and 6 months 3 months and 6 months | — |
Countries
India
Contacts
Public ContactDr Sumaira Khalil
University College of Medical Sciences and GTB Hospital
Outcome results
None listed