Health Condition 1: - Health Condition 2: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Dexmedetomidine: Using Graseby 2000 (smiths medical) infusion pump Group Dexmedetomidine received 1 mcg/kg bolus for 10 mins prior to induction and infusion rate as 0.5 mcg/kg/hr till s
Sponsors
Paras Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1 Patients aged 18 - 65 years. 2 American Society of Anesthesiologists I/II. 3 Elective supratentorial craniotomy
Exclusion criteria
Exclusion criteria: 1 Known allergy to drugs. 2 History of renal,liver, cerebrovascular and cardiovascular (mod/severe) disease. 3 Chronic beta blocker treatment with heart rate or preoperative HR 4 Isolated frontal lobe surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters - Mean arterial pressure( MAP)Timepoint: Baseline values will be recorded (average of 3) prior to start of study drug. At 0,5 and 10 mins hemodynamic parameters and BIS are recorded. Then at induction , intubation and incision. In between recordings at 15 min interval. At stopping study drug and starting atracurium. Followed by stopping atracurium and tapering propofol. Again recordings will be taken at emergence and extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameter SBP and DBP, HR, BIS Requirement of other annaetshetic drugs propofol, atracurium. Vas score post extubation Analgesic requirement. Timepoint: Baseline values will be recorded (average of 3) prior to start of study drug. At 0,5 and 10 mins hemodynamic parameters and BIS are recorded. Then at induction , intubation and incision. In between recordings at 15 min interval. At stopping study drug and starting atracurium. Followed by stopping atracurium and tapering propofol. Again recordings will be taken at emergence and extubation Visual analogue scale till 24 hours post surgery. | — |
Countries
India
Contacts
Public ContactDr Ankita Jaiswal
Paras Hospital
Outcome results
None listed