Health Condition 1: A90- Dengue fever [classical dengue]
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Apollo Childrens Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Participants whose parent(s)/guardian(s) is/are willing and able to give informed consent for participation in the study. 2. Children who are still in shock despite the initial 20ml/kg resuscitation fluid in the initial 6 hours of shock. The resuscitation fluid must be a crystalloid
Exclusion criteria
Exclusion criteria: 1. Patients has evidence of Significant bleeding or drop in HCT requiring transfusion 2. Patients who have already received any colloid prior to enrolment 3. Admission in recovery phase of dengue 4. Patients with chronic renal failure or pre-existing liver failure or pre-existing thrombocytopenia or coagulation disorder (such as ITP or haemophilia). 5. Requirement of CRRT or plasma exchange for indications other than acute kidney injury such as liver failure. 6. Parent(s)/guardian(s) are not willing for enrolment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the safety of synthetic colloid with respect to renal function and coagulation function in paediatric dengue shock syndrome.Timepoint: Day-0; Within 2 hours of initiating the synthetic colloid or albumin Day-1 After 24 hours Day-5 or discharge (whichever is earlier) Day 28 of starting the colloid | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the efficacy of synthetic colloid with respect to the need for â??rescue colloidâ?? and â??fluid-overloadâ?? in pediatric dengue shock syndrome 2. To assess the effect of synthetic colloid with respect to survival in paediatric dengue shock syndrome Timepoint: 1. Within the initial 12 hours of admission to the ICU or high-dependency unit. 2. Day 28 survival | — |
Countries
India
Contacts
Public ContactDr Suchitra Ranjit
Apollo Childrens Hospital
Outcome results
None listed