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diagnostic markers for pulpal disease

Salivary and Gingival Crevicular fluid Levels of NLRP3 in patients diagnosed with Symptomatic Irreversible Pulpitis- A Case Control Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/10/046581
Enrollment
32
Registered
2022-10-18
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Control Intervention1: Healthy Individuals Group 1: Saliva will be collected by the Drool method and Gingival Crevicular Fluid by the Capillary method at baseline only from 16 patients who are caries-

Sponsors

DAX ABRAHAM
Lead Sponsor
Dr Arundeep Singh
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria for Group 1 (healthy individuals) a) Patients age 18-40 years of age b) Patients with no relevant medical history or absence of any systemic conditions c) Non-smokers d) OHI index of 0 and Russel’s Periodontal index (not >0.9) Inclusion Criteria for Group 2 (Experimental Group) a) Patients with carious teeth diagnosed as Symptomatic irreversible pulpitis and Heft Parker Scale reading more than 54. b) Patients with no relevant medical history or absence of any systemic conditions c) OHI index of 0 and Russel’s Periodontal index (not >0.9)

Exclusion criteria

Exclusion criteria: a) Patients with systemic condition or medical illness b) Patients with periodontitis (Russel’s periodontal Index score > 0.9)

Design outcomes

Primary

MeasureTime frame
NLRP3 levels in Saliva and GCF Timepoint: Immediately at the time of collection—

Countries

India

Contacts

Public ContactDAX ABRAHAM

Manav Rachna Dental College

principal.mrdc@mrei.ac.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026