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Transfusion of plasma to ABO not matched transplant patients.

Assessment of changes in the levels of anti-A and anti- B antibody titres in ABO incompatible Hematopoietic transplant recipients after transfusion of donor plasma having A and B secretory substances.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046554
Enrollment
10
Registered
2022-10-17
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C920- Acute myeloblastic leukemia

Interventions

Intervention1: Plasma transfusion: Patient will be transfused with incremental doses of Fresh Frozen plasma(FFP) 5ml/kg up to 20ml/kg. A maximum of 2 adult doses of FFP will be given to a patient. Con

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ABO-incompatible hematopoietic transplant recipients

Exclusion criteria

Exclusion criteria: 1.Donors plasma with no SAS (non secretors) 2.Donors who are tested positive for transfusion transmissible infection Donor - Department of Transfusion medicine Patient - Medical oncology department

Design outcomes

Primary

MeasureTime frame
To assess the change in anti-A anti-B antibody titre levels before and after transfusion of donor plasma having A and B secretary substances in ABO incompatible hematopoietic transplant recipientsTimepoint: Within 24 hours of intervention—

Secondary

MeasureTime frame
To identify the clinical factors associated with change in anti-A, anti-B titres in ABO incompatible transplant recipients following AB donor plasma transfusion. Timepoint: Immediately after intervention within 24 hours and 4 weeks—

Countries

India

Contacts

Public ContactRaushan Afroz

Jawaharlal Institute of Postgraduate Medical Education and Research

drabhigowda@gmail.com9008255888

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026