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To Compare which drug is better out of Injection Lignocaine , Esmolol And Magnesium Sulphate to Decrease the bodyâ??s stress response to Inserting a tube in trachea.

A Comparative Study of Intravenous Lignocaine, Esmolol And Magnesium Sulphate For Attenuation Of Sympathoadrenal Response To Endotracheal Intubation.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046496
Enrollment
87
Registered
2022-10-14
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration Health Condition 2: 4- Measurement and Monitoring

Interventions

Intervention1: Attenuation of Sympathoadrenal Response to Endotracheal Intubation by Drugs: patients are divided into 3 random groups. Only 1 drug will be given to 1 patient. Once the drug is chosen r

Sponsors

ABVIMS and Dr RML Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society of Anaesthesiology(ASA) Physical status I and II. 2. Elective surgical procedure. 3. Either sex. 4. Consenting adults of age 18-55 years.

Exclusion criteria

Exclusion criteria: 1. A known sensitivity to any study drug. 2. Pregnant females. 3. Patient with chronic Hypertension or Diabetes Mellitus. 4. Patient on beta- blocker. 5. Patient with history of cardiac or respiratory disease. 6. Patient with anticipated difficult airway. 7. Patient with impaired kidney or liver function.

Design outcomes

Primary

MeasureTime frame
Hemodynamic response to Endotracheal Intubation (HR,SBP,DBP,MAP) Timepoint: Pre-operative 1 minute after Endotracheal Intubation 3 minutes after Endotracheal Intubation 5 minutes after Endotracheal Intubation—

Secondary

MeasureTime frame
Biochemical markers of stress response( Serum Norepinephrine and blood sugar)Timepoint: Baseline(at arrival in OT) 5min after Endotracheal Intubation—

Countries

India

Contacts

Public ContactDr Vishal Dahiya

Department of Anaesthesia,ABVIMS and Dr. RML hospital, New Delhi

lalitachaudhary055@gmail.com9968299710

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026