Anaesthesia without the use of opioids in patients undergoing Head and Neck Cancer Surgeries

Comparison of Long-term outcomes between Opioid Free Anaesthesia and Opioid Based Anaesthesia in Head and Neck Cancer Surgeries -A Pilot Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046485

Enrollment

Registered

2022-10-14

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx Health Condition 3: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx

Interventions

Intervention1: Opiod free anaesthesia (OFA): Patients in group OFA will receive opioid free anaesthesia. These patients will receive pregabalin 2 hr before surgery and then 2 days postoperatively, dex

Eligibility

Inclusion criteria

Inclusion criteria: Consenting ASA grade I â?? II patients, aged 20-65 years, undergoing head and neck cancer surgeries

Exclusion criteria

Exclusion criteria: Patients with a history of postoperative nausea, prior allergy to local anaesthetics (LA), chronic pain of any aetiology or patients who are already on opioids, patients with coagulopathies or having cognitive dysfunction.

Design outcomes

Primary

Measure	Time frame
Percentage of patients with CPSP in both the groupsTimepoint: At the end of 1st week,4th week,8th week and 12th week.	—

Secondary

Measure	Time frame
Hospital Anixety and Depresscion (HADS) scale, Activity assessment scale,Post-operative nausea and vomiting (PONV) score, rescue analgesic consumption in first 24 hrs, Activity Assessment Score (AAS), Hospital Anxiety and Depression Scale (HADS), Pain Detect Questionnaire (PDQ), Neuropathic Pain Symptom Inventory NPSI, (Douleur Neuropathique 4 Questions) DN-4 score, Short form survey (SF-12) scoreTimepoint: HADS AND AAS score in preoperative period Pain intensity using NRS at 3rd, 6th, 12th and 24th hr, end of 1st week, 4th week, 8th week and 12th week postoperatively. PONV scores in first 24 hrs Rescue analgesic consumption in first 24 hrs PDQ, NPSI and DN-4 scores at 1st week, 4thweek, 8th week and 12th week postoperatively SF-12 score at 1st week,4th week, 8th week and 12th week postoperatively	—

Measure

Time frame

Hospital Anixety and Depresscion (HADS) scale, Activity assessment scale,Post-operative nausea and vomiting (PONV) score, rescue analgesic consumption in first 24 hrs, Activity Assessment Score (AAS), Hospital Anxiety and Depression Scale (HADS), Pain Detect Questionnaire (PDQ), Neuropathic Pain Symptom Inventory NPSI, (Douleur Neuropathique 4 Questions) DN-4 score, Short form survey (SF-12) scoreTimepoint: HADS AND AAS score in preoperative period Pain intensity using NRS at 3rd, 6th, 12th and 24th hr, end of 1st week, 4th week, 8th week and 12th week postoperatively. PONV scores in first 24 hrs Rescue analgesic consumption in first 24 hrs PDQ, NPSI and DN-4 scores at 1st week, 4thweek, 8th week and 12th week postoperatively SF-12 score at 1st week,4th week, 8th week and 12th week postoperatively

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Countries

India

Contacts

Public ContactDr Geetanjali T Chilkoti

Department of Anesthesiology and Critical care,UCMS and GTB Hospital,dilshad garden delhi 110095

kataria99908@gmail.com8882611349

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026