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Comparison of three commonly used drugs: Dexmedetomidine, Clonidine, and Magnesium Sulphate to find the best drug in reducing blood pressure, blood loss and improved surgical outcome during Sinus Surgery.

Comparison of Dexmedetomidine, Clonidine and Magnesium Sulphate for induced hypotension during functional endoscopic sinus surgery: A randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046459
Enrollment
114
Registered
2022-10-13
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: J348- Other specified disorders of noseand nasal sinuses

Interventions

Intervention1: Injection Dexmedetomidine: Injection Dexmedetomidine iv 0.75 �µg/kg in 50 ml of saline over 20 minutes followed by 0.3-0.5 �µg/kg/hour infusion. Control Intervention1: injection Clo

Sponsors

Dr Akshatha G Kamath
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II physical Status patients

Exclusion criteria

Exclusion criteria: Hemodynamically unstable patients Uncontrolled hypertension/ coronary artery disease/ Heart blocks/ Autonomic neuropathy/ Renal dysfunction/ Hepatic dysfunction/ Cerebral insufficiency Patients allergic to the drugs being studied Patients with coagulopathy, bleeding disorders, platelet dysfunction Patients with vascular/congenital anomalies of nasal mucosa Pregnancy

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of Dexmedetomidine, Clonidine and Magnesium Sulphate in inducing controlled hypotensionTimepoint: Measured at baseline, after the loading dose, after induction, 1 minute after intubation, 5 minutes after intubation and thereafter every 10 minutes until shifting of the patient to the recovery area.—

Secondary

MeasureTime frame
Calculating the estimated blood lossTimepoint: Measured every 30 Minutes—

Countries

India

Contacts

Public ContactDr Akshatha G Kamath

St Johns medical college and hospital

rashmidr17@gmail.com9482903401

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026