Health Condition 1: G09- Sequelae of inflammatory diseasesof central nervous system
Conditions
Interventions
Intervention1: Conservative Oxygen Therapy Group:
Target Spo2 88-92%/Pao2-55-70mmHg: Participants allocated to the Conservative oxygen therapy group will receive supplemental oxygen and ventilator se
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: All premorbid well children between the age group of >28 days to 12 completed years admitted to PICU with a diagnosis of non-traumatic coma requiring invasive ventilation will be enrolled within 48 hrs of initiation of mechanical ventilation
Exclusion criteria
Exclusion criteria: All children with severe acute respiratory distress syndrome (Appendix 10), Traumatic brain injury, congenital heart disease, previously known/chronic neurological illness, pulmonary hypertension, Sickle cell disease and parents who refused for consent will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow outcome scale extended (GOS-E)Timepoint: Discharge,3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Adequacy of recruitment rates and protocol compliance with respect to duration of oxygen targetsTimepoint: At time of extubation from ventilation;Length of PICU stay, Ventilator free daysTimepoint: At the time of PICU discharge or transfer from PICU;QUALITY OF LIFE,POPC,PCPCTimepoint: At discharge, 3months;Survival statusTimepoint: 28days, 90 days;VIS, SOFATimepoint: Day 0,1,2,3,4 till child is discharged from PICU | — |
Countries
India
Contacts
Public ContactDr Arun Bansal
PGIMER
Outcome results
None listed