Health Condition 1: M170- Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention1: autologous platelet-rich plasma: the intraarticular platelet-rich plasma will be injected with the patient in a seated position with the knee in 90 degrees of flexion using a 21G needle
Sponsors
All india institute of medical sciences Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: primary osteoarthritis knee diagnosed with ACR criteria with age more than 50 years and presence of crepitus on active motion and less than 30 minutes of morning stiffness with bony tenderness and bony overgrowth with no palpable warmth of synovium with KL grade 1 and 2 and nonresponders to standard of care for oa knee and radiological confirmed oa knee
Exclusion criteria
Exclusion criteria: secondary oa knee and any prior knee surgery and any connective tissue disorder and serious neurological or psychiatric disorder and patient on anticoagulants and any fracture and vascular disease of lower limbs and joint effusions and uncontrolled diabetes mellitus and blood platelet count less than or equal to one lakh fifty thousand per microlitres and hepatitis b c or hiv
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC scoreTimepoint: at baseline then 4 weeks then 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| articular cartilage thicknessTimepoint: at baseline then at 12 weeks;efficacy of standard of care for osteoarthritis kneeTimepoint: at 12 weeks;serum CRP levelsTimepoint: at baseline then at 12 weeks | — |
Countries
India
Contacts
Public ContactDr Mohit Kishore Srivastava
Associate professor and Head of Department, Department of PMR
Outcome results
None listed