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Bisphosphonate therapy in idiopathic avascular necrosis of femoral head in adolescents and young adults.

A prospective clinical case study on Bisphosphonate combination therapy in the management of Idiopathic Avascular Necrosis of the Femoral Head in Adolescents and young adults.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046412
Enrollment
40
Registered
2022-10-12
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M858- Other specified disorders of bonedensity and structure

Interventions

Intervention1: Bisphosphonate combination therapy: Infusion Zolendronic acid 5mg iv slowly once in year followed by Oral Alendronate 70 mg before breakfast weekly starting after one week of infusion w

Sponsors

Department of Orthopedics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients with radiological changes suggestive of avascular necrosis of hip who will give informed consent and willing for follow up. With Ficat arlet stage 1 or 2.

Exclusion criteria

Exclusion criteria: Patient with renal function impairment. Patient with ficat arlet stage 3 or more. Post traumatic avascular necrosis of femoral head.

Design outcomes

Primary

MeasureTime frame
Funcional outcome by pain visual analogue scale and Modified Harris hip score. Radiological outcome by Ficat arlet staging.Timepoint: Immediate after therapy, every 8 weeks for 24 weeks then every 6 months untill 2 years.—

Secondary

MeasureTime frame
Need for other intervention like surgical intervention if there is no improvement in functional and radiological outcome.Timepoint: Every 6 monthly.—

Countries

India

Contacts

Public ContactDr Kamlesh Sukhwal

SMS Medical College

drnarendra189@gmail.com9414072387

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026