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Effects of Aprepitant and dexamethasone in prevention of nausea and vomiting after laparoscopic cholecystectomy

Comparison of the effects of Aprepitant and Dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy: A double blind randomised trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046372
Enrollment
84
Registered
2022-10-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: APREPITANT: PATIENT IN GROUP I WILL RECEIVE 80 MG ORAL APREPITANT 3 HOURS BEFORE INDUCTION OF ANAESTHESIA Control Intervention1: DEXAMETHASONE: PATIENTS IN GROUP II WILL RECEIVE 8 MG D

Sponsors

Intramural project funded by Research cell of Rajendra Institute Of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA GRADE I & II PATIENTS SCHEDULED FOR ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY SURGERY

Exclusion criteria

Exclusion criteria: PATIENTS WHO HAD A HISTORY OF DRUG ABUSE, HYPERSENSITIVITY REACTION, NAUSEA AND RECEIVED ANTIEMETIC BEFORE SURGERY WITHIN 24 HOURS, PREGNANCY, BREASTFEEDING STATUS

Design outcomes

Primary

MeasureTime frame
The primary efficacy variable will be episodes of nausea and vomiting in the early and late postoperative period in first 24 hours. Timepoint: first 24 hours after surgery.—

Secondary

MeasureTime frame
The incidence of any adverse reaction to treatment in the two experimental groups will be recorded Timepoint: 24 hours—

Countries

India

Contacts

Public ContactWASIMUL HODA

Assistant Professor, Department of Anesthesiology, Rajendra Institute of Medical Sciences

wasu077@gmail.com8797770602

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026