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Effect of changes in treatment based on measurement of Procalcitonin on the duration of antibiotics and outcome in patients with bacterial infections

Effect of a Procalcitonin based algorithm on the duration of antibiotic therapy and outcome in patients with uncomplicated bacterial infections: A Non-randomised control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046367
Enrollment
180
Registered
2022-10-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A499- Bacterial infection, unspecified

Interventions

Intervention1: Serum Procalcitonin being made available to the treating resident.: In the interventional arm a blood sample will be drawn for estimation of procalcitonin levels on days 3 and 7. The re

Sponsors

Jawaharlal Institute of Post Graduate Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients admitted in the Department of Medicine with a suspected bacterial infection receiving antibiotic therapy

Exclusion criteria

Exclusion criteria: Hemodynamic instability persisting for more than 48 hours Patients who continue to worsen after 72 hours of initial antibiotic therapy Patients shifted to ICU/HDU Presence of an abscess Neutropenic patients/ or receiving steroids/ immunosuppressive agents/ PLHA/ hematological malignancy Melioidosis, scrub typhus, Typhoid fever Bacterial meningitis, septic arthritis, Infective endocarditis Hospital acquired infection (fever starting 48 hours after hospitalisation) including CRBSI Patients who are discharged within 5 days of hospitalisation

Design outcomes

Primary

MeasureTime frame
To study the effect of a procalcitonin based algorithm on the duration of treatment with antibiotics and outcomes in patients with uncomplicated bacterial infections.Timepoint: Serum Procalcitonin will be measured on days 3 and 7. Patients will also be followed up after 1 month.—

Secondary

MeasureTime frame
To study the cost effectiveness of procalcitonin based algorithmTimepoint: Serum Procalcitonin will be measured on days 3 and 7. Patients will also be followed up after 1 month.—

Countries

India

Contacts

Public ContactDr Suryanarayana BS

Jawaharlal Institute of Post Graduate Medical Education and Research

sreeramadamini@gmail.com9441256596

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026