Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: EUS guided coil embolization and n-butyl cyanoacrylate glue: Under the EUS guidance, gastric varices will be localized and its afferent pathway will be identified in Doppler study. Afte
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Cirrhosis with acute variceal bleeding 2. GOV2 and IGV1 3. Age between 18-65 years 4. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Variceal bleeding secondary to causes other than cirrhosis 2. Variceal bleeding from EV 3. Patients with malignancy/disseminated intravascular coagulation (DIC)/known coagulopathic disorder (hemophilia) apart from cirrhosis. 4. History of intake of platelets inhibitors (e.g., aspirin, clopidogrel) and drugs affecting coagulation cascade (e.g., vitamin K antagonists) within past 7 days 5. Pregnant women 6. History of underlying hypercoagulable/ hypocoagulable states e.g. paroxysmal nocturnal hemoglobinuria (PNH), and polycythemia vera. 7. Patients with refractory shock 8. Sepsis/ACLF 9. Contraindication to endoscopy 10. Not willing to provide consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To compare the rebleed rate between the EUS-guided coil embolization and glue injection with endoscopic cyanoacrylate glue injection and BRTO at 1 yearTimepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. All-cause mortality at 1 year 2. Grade of esophageal varices at 1, 3, 6, and 12 months 3. Complications and adverse events at 1, 3, 6, and 12 months Timepoint: 1. 1 Year 2. 1,2,3,6, and 12 months 3. 1,2,3,6, and 12 months | — |
Countries
India
Contacts
Public ContactDr Deepak Gunjan
All India Institute of Medical Sciences
Outcome results
None listed