Comparison of continuous drips of two different medicines to prevent fall in BP during caesarean deliveries

COMPARISON OF MEPHENTERMINE AND NOREPINEPHRINE INFUSIONS FOR PREVENTION OF POST-SPINAL HYPOTENSION DURING ELECTIVE CAESAREAN SECTION – A RANDOMISED, DOUBLE-BLIND TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046315

Enrollment

Registered

2022-10-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: Mephentermine Group: Prophylactic infusion of mephentermine 600 mcg/ml started at 60ml/hr using an infusion pump and the rate titrated according to blood pressure will be used to mainta

Eligibility

Inclusion criteria

Inclusion criteria: Healthy mothers with term, uncomplicated, singleton pregnancy scheduled to undergo elective caesarean section under spinal anaesthesia

Exclusion criteria

Exclusion criteria: Maternal complications, multiple gestation, placental or cord complications; known fetal abnormality; Patients with absolute or relative contra-indications for spinal anaesthesia

Design outcomes

Primary

Measure	Time frame
Umbilical artery pHTimepoint: Delivery of baby	—

Secondary

Measure	Time frame
Apgar scores at 1 and 5 minutes, Incidence of fetal acidosis, Total volume of vasopressor given, Number of episodes of hypotension/hypertension, Incidence of bradycardia/ tachycardia/ arrhythmias, Incidence of nausea, vomiting, dizziness or any other complicationsTimepoint: Delivery of baby	—

Countries

India

Contacts

Public ContactDr Niriksha Kumari

University College of Medical Sciences and Guru Teg Bahardur Hospital

medhamohta@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026