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Sequential Administration of egg development medications to the women having polycystic ovarian disease who were not responding to clomiphene citrate and treated with 3 months of oral contraceptive pill for 3 months to create hormonal balance .

A Comparison of Sequential use of Human Menopausal Gonadotropin Following Clomiphene Citrate or Letrozole for Ovulation Induction In Clomiphene Resistant PCOS women Pretreated with Combined Oral Contraceptives- a Randomized Control Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046305
Enrollment
140
Registered
2022-10-10
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N970- Female infertility associated withanovulation

Interventions

Intervention1: sequential ovulation induction in women having pcod and pretreated with 3 cycles of combined oral contraceptive pills: 1. 3 cycles( 3 months) of combined oral contraceptive pills (dosag

Sponsors

JIPMER Intramural Research Fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Clomiphene citrate resistant polycystic ovarian syndrome women who had pretreatment with OCPs 2 BMI not more than 28 3 Normal Semen Analysis, according to 2020 WHO criteria 4 Bilateral patent tubes

Exclusion criteria

Exclusion criteria: 1 Associated with Uterine or adnexal pathology as a cause for infertility . 2 History of pelvic surgery or pelvic inflammatory disease 3 Presence of Ovarian cysts 4 Thyroid or prolactin dysfunction 5 Any sensitivity to the drugs used. 6 Any history suggestive of high risk of thrombosis

Design outcomes

Primary

MeasureTime frame
To Compare the efficacy Sequential Clomiphene Citrate /Letrozole with human Menopausal Gonadotropin for ovulation induction in CC resistant women with PCOS pretreated with OCPs containing Ethinyl estradiol 30ug and Drosperinone 3mg.Timepoint: outcome assessed at around day 16- day 19 in each cycle for 3 months to look for ovulation after follicular rupture i.e, in the 3rd week of each cycle—

Secondary

MeasureTime frame
To compare the pregnancy rate and live birth rate between both the gruopsTimepoint: 3 - 6 months—

Countries

India

Contacts

Public ContactDr Chitra T

Jawaharlal Institute of Postgraduate Medical Education & Research

drchitra@yahoo.com9488818644

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026