Comparison of ketamine with tramadol in combination with acetaminophen for patients with abdominal pain presenting to the emergency department

Comparison of sub dissociative dose ketamine and tramadol in combination with acetaminophen for acute pain management in patients with abdominal pain presenting to the emergency department – An exploratory randomized double-blind study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046261

Enrollment

Registered

2022-10-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R109- Unspecified abdominal pain

Interventions

Intervention1: Low dose ketamine: Ketamine 0.1 - 0.3 mg/kg in 100 ml over 15 minutes Control Intervention1: Inj. Tramadol: 1mg/kg in 100 ml NS over 15 minutes

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 years and older. 2. Patients presenting to the emergency with abdominal pain within 7 days of onset. 3. Initial pain score of 4 or more on a standard 11-point (0-11) numerating rating scale.

Exclusion criteria

Exclusion criteria: Not willing to give consent. 2. Pregnancy 3. Altered mental status 4. Allergy to ketamine, opioids and acetaminophen 5. Severe hepatic insufficiency 6. Unstable vital signs (systolic blood pressure <90 or >180 mmHg, pulse rate of <50 or >150 per minute, respiratory rate of >30 or <10 per minute.) 7. Ischemic heart disease 8. Head injury 9. Stroke 10. Acute alcohol intoxication 11. History of drug abuse 12. Psychiatric illness

Design outcomes

Primary

Measure	Time frame
To assess and compare the change in pain scores in the two groups measured by numerical rating scale (NRS) at 30 minutesTimepoint: 30 minute	—

Secondary

Measure	Time frame
1. To assess and compare the change in pain score measured by NRS at 15min for onset of pain reliefTimepoint: 15 minutes;2. To assess and compare the change in pain score 60 and 120 minutes respectivelyTimepoint: 60 minutes and 120 minutes;3. To assess the incidence of adverse effects of the two groupsTimepoint: 0, 30, 60 and 120 minutes	—

Countries

India

Contacts

Public ContactAnirban

ALL INDIA INSTITUTE OF MEDICAL SCIENCES, RISHIKESH

poonam.em@aiimsrishikesh.edu.in8477987835

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026