A COMPARISON BETWEEN INTRAVENOUS BOLUS DOSES OF MEPHENTERMINE AND NOREPINEPHRINE DURING SUBARACHNOID BLOCK FOR LSCS

A COMPARATIVE ASSESSMENT OF INTERMITTENT INTRAVENOUS BOLUS NOREPINEPHRINE AND MEPHENTERMINE DURING SUBARACHNOID BLOCK FOR LOWER SEGMENT CAESAREAN SECTION

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/10/046224

Enrollment

Registered

2022-10-06

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: mephentermine bolus according to blood pressure of the patient: blood pressure management in patients undergoing lower segment caesarean section under subarachnoid block Control Interve

Eligibility

Inclusion criteria

Inclusion criteria: ASA GRADE 1 AND 2; FULLTERM NON LABORING SINGLETON PREGNANCY

Exclusion criteria

Exclusion criteria: 1.MULTIPLE PREGNANCIES 2.FETAL DISTRESS 3.PARTURIENTS HAVING CONTRAINDICATIONS TO SUBARACHNOID BLOCK LIKE LOCAL INFECTION, COAGULATION ABNORMALITIES OR ON ANTICOAGULANT MEDICATION 4.PARTURIENTS WITH HYPERTENSIVE DISORDERS OF PREGNANCY AND OTHER HIGH RISK PREGNANCIES, MEDICAL COMORBIDITIES, HEMOGLOBIN 5.HEMODYNAMIC INSTABILITY 6.PARTURIENTS ON DRUGS WHICH CAUSE INTERACTIONS WITH THE STUDY DRUGS LIKE TRICYCLIC ANTIDEPRESSANTS, MONOAMINE OXIDASE INHIBITOR ETC 7.PARTURIENTS WITH HEIGHT/LENGTH 180CM 8.DRUG ALLERGIES

Design outcomes

Primary

Measure	Time frame
NUMBER OF INTERMITTENT INTRAVENOUS BOLUS DOSES OF NOREPINEPHRINE OR MEPHENTERMINE REQUIRED TO TREAT SPINAL INDUCED HYPOTENSIONTimepoint: TIME (IN MINUTES) TAKEN FOR FIRST HYPOTENSIVE EPISODE & TIME (IN MINUTES) OF FURTHER EPISODES OF HYPOTENSION REQUIRING BOLUS DOSES OF NOREPINEPHRINE OR MEPHENTERMINE	—

Secondary

Measure	Time frame
1. Time of first hypotensive episode 2. Number and timing of episodes of hypotension and reactive hypertension 3. To compare the number and timing of Bradycardia , Bradycardia requiring treatment and tachycardia. 4. To note maternal complications shivering, headache vomiting/nausea and local tissue ischemia. 5. To compare the effect of drugs on the fetus in both the groups : APGAR score at 1min & 5min Timepoint: 1. Number and timing of episodes of hypotension and reactive hypertension 2. To compare the number and timing of Bradycardia , Bradycardia requiring treatment and tachycardia. 3. To note maternal complications shivering, headache vomiting/nausea and local tissue ischemia. 4. To compare the effect of drugs on the fetus in both the groups : APGAR score at 1min & 5min	—

Measure

Time frame

1. Time of first hypotensive episode 2. Number and timing of episodes of hypotension and reactive hypertension 3. To compare the number and timing of Bradycardia , Bradycardia requiring treatment and tachycardia. 4. To note maternal complications shivering, headache vomiting/nausea and local tissue ischemia. 5. To compare the effect of drugs on the fetus in both the groups : APGAR score at 1min & 5min Timepoint: 1. Number and timing of episodes of hypotension and reactive hypertension 2. To compare the number and timing of Bradycardia , Bradycardia requiring treatment and tachycardia. 3. To note maternal complications shivering, headache vomiting/nausea and local tissue ischemia. 4. To compare the effect of drugs on the fetus in both the groups : APGAR score at 1min & 5min

—

Countries

India

Contacts

Public ContactSHAHNA ALI

JAWAHARLAL NEHRU MEDICAL COLLEGE, ALIGARH MUSLIM UNIVERSITY

drshahna.farhan@gmail.com9411979684

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026