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Correlation Of Genetics With Post Operative Nausea And Vomiting In Patients Undergoing Major Elective Surgery

To Evaluate Correlation Of SS-Genotype Of 5HTTLPR Gene With Post Operative Nausea And Vomiting In Patients Undergoing Major Elective Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/10/046211
Enrollment
94
Registered
2022-10-06
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

None listed

Sponsors

Lok Nayak and associated hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Undergoing general anaesthesia for elective abdominal, gynaecological, ear, nose and throat surgeries 2)American Society of Anaesthesiologists physical status I-II 3)Patients of either sex older than 18 years

Exclusion criteria

Exclusion criteria: 1)Pregnancy 2)Psychiatric illness or patients with mental retardation

Design outcomes

Primary

MeasureTime frame
Correlation between post - operative nausea and vomiting and genotypes of 5-HTTLPR, rs 4795541Timepoint: 0 hours, 6 hours, 12 hours, 24 hours—

Secondary

MeasureTime frame
Correlation between different genotypes of 5-HTTLPR (rs 4795541 and rs25531) and amount of postoperative anti-emetic medications consumption -Correlation between genotypes of 5-HTTLPR, rs 4795541and rs25531) and Apfel score for risk of PONV Timepoint: 0 hours, 6 hours, 12 hours, 24 hours—

Countries

India

Contacts

Public ContactDR ADITYA TIWARI

Maulana Azad Medical College

kirtinath@gmail.com09958183905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026