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To compare the effect of esmolol v/s dexmedetomidine on blood pressure and heart rate during and after laryngoscopy and endotracheal intubation in patients undergoing elective laprascopic gynecological surgeries.

COMPARISON OF ESMOLOL VERSUS DEXMEDETOMIDINE FOR SUPPRESSION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC GYNECOLOGICAL SURGERY: A RANDOMIZED INTERVENTIONAL STUDY AT SMS MEDICAL COLLEGE,JAIPUR-DURING 2021-2023

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/10/046140
Enrollment
60
Registered
2022-10-04
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N72- Inflammatory disease of cervix uteri Health Condition 2: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems

Interventions

Intervention1: Intravenous DEXMEDETOMIDINE: Intravenous DEXMEDETOMIDINE(1microgram/kg) will be given to determine hemodynamic response from baseline laryngoscopy and intubation Control Intervention1:

Sponsors

Department of anaesthesiology Sawai mansingh medical college and attached hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade 1-2. 2.patients body weight 40-70 kgs. 3.undergoing laparoscopic gyencological surgery.

Exclusion criteria

Exclusion criteria: 1.patients not willing to give consent. 2.patients with anticipated difficult airway and laryngoscopy time more than 20 seconds. 3. Chronic disease -hypertension , diabetes,hepatic disease. 4.patients on beta blockers. 5.pregnant and lactating women.

Design outcomes

Secondary

MeasureTime frame
To determine proportion of cases who developed the side effects after administrating drugTimepoint: 1,3,5,7,10,30min—

Primary

MeasureTime frame
To determine the difference in change in hemodynamic response from baseline after administrating esmolol and dexmedetomidine during laryngoscopy and endotracheal intubationTimepoint: At 1 min 3 min 5 min 7 min 10 min and at 20 min—

Countries

India

Contacts

Public ContactDr Dharmpal Atal

Sawai man Singh medical college Jaipur

chatterjee.chandrashekhar@gmail.com9828088092

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026