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Comparison b/w efficiency of bone graft derived from animals with advanced human blood clot & bone graft derived from animals with liquified human blood clot in the treatment of bony defects in chronic� gum� disease

Comparative Clinical and Radiographic Evaluation of the Efficacy of Bovine Derived Xenograft (Fix-Oss ââ??¢) with Advanced Platelet Rich Fibrin Plus (A-PRF plus) and Bovine Derived Xenograft (Fix-Ossââ??¢) with Injectable Platelet Rich Fibrin (i-PRF) Used in the Treatment of Intrabony Defects in Chronic Periodontitis Patients- A Randomized Clinical Trial

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/046028
Enrollment
44
Registered
2022-09-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Bovine Derived Xenograft with Injectable Platelet Rich Fibrin (i-PRF): Bovine Derived Xenograft (Fix-Oss) with Injectable Platelet Rich Fibrin (i-PRF) Control Intervention1: Bovine Deri

Sponsors

Dr Jayati Pandit
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients in the age group between 30-60 yrs. 2)patients diagnosed with Chronic Periodontitis. 3)Patients who are non smokers or do not consume tobacco in any other form. 4)Patients are in good systemic health with no contraindication to periodontal surgery. 5) Patients having pocket depths >5mm, intraosseous defects > 3mm and with radiographic evidence of vertical / angular bone loss in the affected sites. 6) Involved teeth to be vital and asymptomatic.

Exclusion criteria

Exclusion criteria: 1) One-walled osseous defects. 2) Patients suffering from any systemic diseases or with a compromised immune system. 3) Patients who had received any type of periodontal therapy for the past 6 months. 4) Patients taking immunosuppressant drugs like corticosteroids. 5) Patients with a known history of allergy to Doxycycline or Chlorhexidine or any other medicine used in the study. 6) Patients showing unacceptable oral hygiene compliance during / after Phase I periodontal therapy. 7) Patients taking any drug known to cause gingival enlargement. 8) Pregnant and/or lactating mothers.

Design outcomes

Primary

MeasureTime frame
1) Plaque Index (P.I) Tureskey-Gilmore-Glickman Modification of Quigley Hein) 2.Gingival Index (G.I) (Loe and Sillness,1963) 3.Probing Pocket Depth (PPD) 4.Clinical Attachment Level (CAL)Timepoint: 1) At Baseline 2) After 1 month 3) After 3 month 4) After 6 month—

Secondary

MeasureTime frame
The radiographic bone fill will be evaluated using Intraoral Periapical Radiographs of the surgical site.Timepoint: Baseline- at baseline,immediately after the surgery and 6 months post surgery—

Countries

India

Contacts

Public ContactDr Mala Dixit Baburaj

Nair hospital Dental College,Mumbai

maladixit25@gmail.com9223340938

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026