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Comparison of heart rate and blood pressure changes between propofol and ketofol(ketamine and propofol) as sleep inducing agents in patients undergoing keyhole surgeries under general anaesthesia

Comparison of haemodynamic changes between propofol and ketofol as induction agents in patients undergoing laparoscopic surgeries under general anaesthesia-a double blinded randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/046000
Enrollment
70
Registered
2022-09-28
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis

Interventions

Intervention1: ketofol (ketamine plus propofol) as induction agent: In laparoscopic surgeries under general anaesthesia,ketofol(1mg/kg propofol plus ketamine 1mg/kg(10mg/ml dilution) diluted to 20 ml

Sponsors

S NIJALINGAPPA MEDICAL COLLEGE AND HSK HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 .ASA 1 and ASA 2 patients 2.Patients aged between 18-60 years 3.Patients undergoing elective laparoscopic surgery.

Exclusion criteria

Exclusion criteria: 1. Patient refusal to give consent �  2. Patients with uncontrolled hypertension �  3. Patients with uncontrolled diabetes mellitus �  4. Patients with history of psychiatric illness �  5. Pregnant patients �  6. Patients with BMI >30kg/m2 �  7. Patients with known allergy to study drugs

Design outcomes

Primary

MeasureTime frame
We expect ketofol to have better haemodynamic stability than propofol as induction agent in laparoscopic surgeries under general anaesthesia. Timepoint: 3 hours—

Secondary

MeasureTime frame
we expect the incidence of post operative nausea ,vomiting and post operative shivering to be less with ketofol than with propofolTimepoint: 12 hours—

Countries

India

Contacts

Public ContactDR THANUJA J

S.NIJALINGAPPA MEDICAL COLLEGE

mahindra2936@gmail.com9449551654

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026