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HEREDITARY CHANGES SEEN IN GUM DISEASE PATIENTS AMONG NORTH INDIAN POPULATION

ASSOCIATION OF TNF-�± AND TGF-�²1 WITH PERIODONTITIS PATIENTS IN NORTH INDIAN POPULATION

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/09/045992
Enrollment
384
Registered
2022-09-28
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Control Intervention1: Observational study: NIL

Sponsors

Dr Ruchi Pandey
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group A (Healthy subjects) 1. Gingival Bleeding index �10%. 2. No Clinical attachment loss (CAL) (Tonetti et al 2017) 3. Pocket Probing depth (PPD) � 3mm. (Tonetti et al 2017) 4. No radiographic Bone loss. (Tonetti et al 2017) 5. Plaque scores � 1. Group B ( Generalized Periodontitis subjects) 1. Gingival Bleeding index more than > 10% 2. Clinical attachment loss � 1mm (Tonetti et al 2017) 3. All grades of periodontitis will be included (% of bone loss 1) (Tonetti et al 2017). 4. Pocket Probing depth (PPD) > 3mm (Tonetti et al 2017). 5. Plaque scores >1.

Exclusion criteria

Exclusion criteria: Group A (Healthy subjetcs): 1. Pregnant and lactating females. 2. Subjects using any form of tobacco. 3. Subjects with known systemic diseases /syndromes. 4. Subjects showing recession due to causes other than induced by plaque/ calculus accumulation. 5. Subjects on any kind of systemic medication past 3 months and periodontal therapy past 6 months. 6. Subjects with nationality other than Indian. Group B (Generalized periodontitis subjects): 1. Pregnant and lactating females. 2. Subjects using any form of tobacco. 3. Subjects with known systemic diseases /syndromes. 4. Subjects showing recession due to causes other than induced by plaque/ calculus accumulation. 5. Subjects on any kind of systemic medication past 3 months and periodontal therapy past 6 months 6. Subjects with nationality other than Indian.

Design outcomes

Primary

MeasureTime frame
Tumour necrosis factor Ã?± (-308G/A) and Transforming growth factor Ã?² 1 (-509 C/T) polymorphisms if found associated with periodontitis in population can be used as potential tool for identifying susceptible individuals and will aid in early identification of periodontally susceptible patientsTimepoint: Baseline—

Secondary

MeasureTime frame
To compare TNF-Ã?± and TGF- Ã?²1polymorphisms in periodontitis patientsTimepoint: baseline—

Countries

India

Contacts

Public ContactDr ruchi pandey

Manav Rachna Dental College, Faridabad

sumit.mrdc@mrei.ac.in9891353960

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026