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Comparative Efficacy of Gingival Application of Injectable Platelet Concentrate and Green Tea Gel as an Add-On in the treatment of Periodontitis

Comparative Efficacy of Local Subgingival Application of Injectable Platelet Rich Fibrin and (-)-Epigallocatechin Gallate Gel as an Adjunct to Scaling and Root Planing: A Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045964
Enrollment
90
Registered
2022-09-27
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Topical subgingival application of injectable platelet-rich fibrin (I-PRF): Scaling and Root Planing followed by topical subgingival application of injectable platelet-rich fibrin (I-PR

Sponsors

Dr Priyadarshika Kumari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients within the age of 35 to 60 years 2. Presence of minimum of 16 natural teeth excluding 3rd molars 3. Systemically healthy patients with periodontitis (Stage II, III) clinically diagnosed based on 2017 World Workshop on the Classification of Periodontal and Peri- implant diseases and conditions.[12] Periodontitis patients with Bleeding on probing � 40% of teeth, clinical attachment loss � 3mm in more than 30% of the sites and probing pocket depth �5 mm with at least 6 teeth and radiographic bone loss ranging from coronal to middle third or beyond.

Exclusion criteria

Exclusion criteria: 1. Patients with any systemic diseases 2. Patients with allergy to green tea or product of green tea. 3. Patients with history of periodontal therapy within past 6 months 4. Patients with history of antibiotic intake within past 3 months 5. Patients with history of anti-inflammatory drug therapy within 3 months 6. Furcation involvement 7. Pregnancy or lactation 8. Current or former smokers 9. Patients with any intra oral lesions

Design outcomes

Primary

MeasureTime frame
Clinical Attachment level (CAL) Gingival Margin Level(GML) Probing Pocket depth(PPD) Timepoint: At baseline, 3 months 6 months—

Secondary

MeasureTime frame
Bleeding on Probing(BOP) Plaque Index(PI) Timepoint: At baseline 3 months 6 months—

Countries

India

Contacts

Public ContactDr Sanjeela Guru

Vydehi Institute of Dental Sciences and Research Centre, Bangalore

sanjeelaguru@yahoo.co.in07259665551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026